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Reference details
Synopsis and invited feedback
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| Here we test whether multiplicity, an emergent global property of protein evo-
lution, can be predicted by a neutral and purely probabilistic theory. CoHSI (Con-
servation of Hartley-Shannon Information) embeds information theory in a statis-
tical mechanical framework with the minimal assumption that every microstate is
equiprobable, in effect aggregating all factors contributing to evolution (e.g. muta-
tion, drift, selection, speciation, horizontal transfer of protein-encoding genes, extinc-
tion etc.) to generate predictions of the global equilibrium state (the macrostate) of
molecular evolution. The null prediction of CoHSI theory is a heretofore unknown
global pattern of protein multiplicity that is a distinctive variant of the Zipfian dis-
tribution. We show that the predictions of CoHSI theory are borne out to a high
degree of statistical robustness for the totality of known proteins. Over 13 million
multiplicious proteins exist, ranging from the highly conserved (histones, components
of photosystems and the electron transport chain) to the rapidly evolving viral pro-
teins that are involved in infection and adaptation to novel host species. The proteins
of bacteria, archaea, eukaryotes and viruses, considered separately, also show with
strong statistical support the predicted CoHSI equilibrium distribution. | None yet | 9 |
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Auto-generated: $Revision: 1.67 $, $Date: 2024/01/11 15:04:16 $, Copyright Les Hatton 2001-
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